Coupling endoplasmic reticulum stress to the cell death program

By R. Rao, H. Ellerby, Dale E. Bredesen. Cell Death and Differentiation, 2004

1,079 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/fb53843a80dc0b4eaf04e00bcc73b93bc219b824

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. R. Kaufman
2. D. Ron
3. G. Hotamışlıgil
4. H. Harding
5. S. Oyadomari
6. S. Marciniak
7. Junying Yuan
8. M. Boyce

In Epidemiology

1. R. Kaufman
2. G. Hotamışlıgil
3. D. Ron
4. H. Harding
5. I. Novoa
6. J. Malhotra
7. S. Oyadomari
8. Yuhong Zhang

In Molecular Biology

1. R. Kaufman
2. G. Hotamışlıgil
3. D. Ron
4. H. Harding
5. Jerry M. Adams
6. S. Marciniak
7. S. Oyadomari
8. I. Novoa

Citations in the corpus

• Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease (2010, positive): “CHOP is induced through the PERK pathway, caspase-12 and JNK signaling are activated, and proapoptotic Bcl-2 proteins BAX and BAK are switched on by the IRE1a pathway (Hetz et al., 2006; Rao et al., 2004).”
• Orchestrating the unfolded protein response in health and disease. (2002, background): “However, APAF1–/– cells are susceptible to ER stress–induced apoptosis, indicating that the mitochondrial pathway is not essential (45).”
• The role of the unfolded protein response in tumour development: friend or foe? (2004, neutral): “fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=840">caspase-7 (Ref”
• CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. (2004, background): “Various downstream effectors of cell death induced by ER stress have been identified (Nakagawa et al. 2000; Rao et al. 2001; Wei et al. 2001); however, the proximal steps that mobilize them during ER stress are poorly understood.”
• Cellular response to endoplasmic reticulum stress: a matter of life or death (2006, background): “For example, ER stress can induce the activation of caspase-9 independent of Apaf-1, the usual mediator of caspase-9 activation.(166) This probably occurs via the direct cleavage of caspase-9 by caspase-12.”
• ER stress and neurodegenerative diseases (2006, background): “Caspase-12 could in turn activate downstream caspases inducing cell death.(22,23) The association of caspase-12 with human”