Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus

By Emily C. Baechler, F. Batliwalla, George Karypis, P. Gaffney, W. Ortmann, Karl J. Espe, Katherine B. Shark, William J Grande, K. M. Hughes, V. Kapur and 2 more. Proceedings of the National Academy of Sciences of the United States of America, 2003

2,263 citations recorded by the source corpus.

Subfields: Immunology, Oncology, Rheumatology

View Paper: https://www.semanticscholar.org/paper/fb15228c2714fa8e846ee058d789d3d32f206fcc

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Jacques Banchereau
2. Yong‐jun Liu
3. G. Trinchieri
4. V. Pascual
5. A. Palucka
6. M. Colonna
7. R. Coffman
8. F. Barrat

In Oncology

1. Jacques Banchereau
2. M. Colonna
3. R. Coffman
4. A. Palucka
5. F. Barrat
6. K. Palucka

In Rheumatology

1. Ling-Ling Chen

Citations in the corpus

• Immune sensing of DNA (2013, neutral): “Role for DNA Sensing in Autoimmunity In addition to microbial DNA, self-DNA also has the potential to trigger innate immune responses, and both type I IFNs and TLR9 have established roles in mouse models of autoimmunity and in human patients with autoimmune disease (Leadbetter et al., 2002; Bennett ”
• Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes. (2005, positive): “To confirm family relationships, all samples were genotyped, as described elsewhere (Baechler et al. 2003), for a set of ∼100 polymorphic markers (ABI, version 2.”
• Netting Neutrophils Are Major Inducers of Type I IFN Production in Pediatric Systemic Lupus Erythematosus (2011, background): “Genomic approaches have shown that >95% of children and 50 to 70% of adults with SLE display a type I IFN signature as measured by peripheral blood mononuclear cell (PBMC) gene expression profiling (9, 10).”
• Activation of the interferon-alpha pathway identifies a subgroup of systemic lupus erythematosus patients with distinct serologic features and active disease. (2005, background): “In light of previous findings suggesting an association of increased disease severity and activity with the IFN signature on microarray (16,17), as well as in vitro data showing a role for RNA- and DNA-containing immune complexes in induction of IFN (14), we predicted that activation of”
• Type I interferon in systemic lupus erythematosus and other autoimmune diseases. (2006, background): “Leukocytes from most adult SLE patients also display a remarkable IFN signature that correlates with disease severity (Baechler et al., 2003).”
• Plasmacytoid dendritic cells in immunity (2004, background): “The expression of type 1 interferon genes and interferon-induced genes represent the most salient molecular 'signatures' of SLE peripheral blood cell”
• Structure and Degradation of Circular RNAs Regulate PKR Activation in Innate Immunity. (2019, positive): “All SLE patients were evaluated with clinically recognized IFN scores (Baechler et al., 2003; Feng et al., 2006; Kirou et al., 2004) (Figure S7C; Table S7).”