H2AX: the histone guardian of the genome.

By O. Fernández-Capetillo, Alicia Lee, Michel C. Nussenzweig, A. Nussenzweig. DNA Repair, 2004

1,076 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/fb0a96cf1873998566f0a0b2e700527508867676

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Citations in the corpus

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins. (2009, positive): “Following the generation of DNA double-strand breaks (DSBs), the neighboring chromatin undergoes extensive modifications initiated by ATM-dependent phosphorylation of histone H2AX (g-H2AX) and culminating at the generation of a distinct compartment capable of retaining various genome caretakers (Fer”
The γ‐H2A.X: Is it just a surrogate marker of double‐strand breaks or much more? (2008, neutral): “X, macroH2A, and H2ABbd (H2A-barbody-deficient) [Ausio and Abbott, 2002; Redon, 2002; Fernandez-Capetillo et al., 2004].”
Phosphorylation of BLM, Dissociation from Topoisomerase IIIα, and Colocalization with γ-H2AX after Topoisomerase I-Induced Replication Damage (2005, background): “-H2AX has been proposed to anchor the broken chromosome ends together and recruit DNA repair elements (5, 20, 23, 45, 53).”
Recruitment of the INO80 complex by H2A phosphorylation links ATP-dependent chromatin remodeling with DNA double-strand break repair. (2004, neutral): “(2004 [this issue of Cell]), lates with impaired formation of repair foci at sites of provide the first demonstration of a link between the damage (Fernandez-Capetillo et al., 2004).”
Targeting Suppressor of Variegation 3-9 Homologue 2 (SUV39H2) in Acute Lymphoblastic Leukemia (ALL) (2015, background): “Phosphorylated histone H2AX (γ-H2AX) is associated with activation of DNA-damage repair pathways and enhanced radio and chemoresistance of cancer cells [21–25].”
γ-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin (2008, background): “When such foci are induced by ionizing radiation, they are referred to as IR-induced nuclear foci (IRIF) (27,28), and their analysis has provided important information on the molecular processes underlying the DDR.”
A census of human RNA-binding proteins (2014, background): “(C) Histone H2Av phosphorylation (H2Av) is a marker for double-stranded DNA breaks, genomic instability and apoptosis (Fernandez-Capetillo et al., 2004; Kotova et al., 2011).”
ROS and the DNA damage response in cancer (2018, background): “Histone H2AX is another chromatin factor that has been extensively studied in the DNA damage response [57].”