ROS and the DNA damage response in cancer

By U. S. Srinivas, B. W. Tan, B. Vellayappan, Anand D. Jeyasekharan. Redox Biology, 2018

1,797 citations recorded by the source corpus.

Reactive oxygen species (ROS) are a group of short-lived, highly reactive, oxygen-containing molecules that can induce DNA damage and affect the DNA damage response (DDR). There is unequivocal pre-clinical and clinical evidence that ROS influence the genotoxic stress caused by chemotherapeutics agents and ionizing radiation. Recent studies have provided mechanistic insight into how ROS can also influence the cellular response to DNA damage caused by genotoxic therapy, especially in the context of Double Strand Breaks (DSBs). This has led to the clinical evaluation of agents modulating ROS in combination with genotoxic therapy for cancer, with mixed success so far. These studies point to context dependent outcomes with ROS modulator combinations with Chemotherapy and radiotherapy, indicating a need for additional pre-clinical research in the field. In this review, we discuss the current knowledge on the effect of ROS in the DNA damage response, and its clinical relevance.

Subfields: Cancer Research, Molecular Biology, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/d3ef635d8e1c3304e37784ffb8d02206bf29690e

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Citations in the corpus

• The Chemistry of Reactive Oxygen Species (ROS) Revisited: Outlining Their Role in Biological Macromolecules (DNA, Lipids and Proteins) and Induced Pathologies (2021, background): “The DNA damage caused by ROS, from endogenous or exogenous sources, has been a significant breakthrough in carcinogenesis research over the last 20 years [22].”