Visualizing the generation of memory CD4 T cells in the whole body

By R. Reinhardt, A. Khoruts, R. Merica, Traci Zell, M. Jenkins. Nature, 2001

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Viral Persistence Alters CD8 T-Cell Immunodominance and Tissue Distribution and Results in Distinct Stages of Functional Impairment (2003, background): “Several recent reports have demonstrated the presence of antigen-specific memory T cells in nonlymphoid tissues (46, 47, 62).”
Anatomical basis of tolerance and immunity to intestinal antigens (2003, background): “, as indicated by the recent findings that antigen-specific memory CD4 + and CD8 + T cells accumulate preferentially in non-lymphoid tissues, in particular the intestinal mucos”
Chemokines and chemokine receptors: positioning cells for host defense and immunity. (2014, background): “These cells therefore preferentially migrate between the blood and spleen compartments and enter peripheral organs, such as the lung, liver, intestinal tract, and kidney (191, 192).”
Dendritic Cells Induce Peripheral T Cell Unresponsiveness under Steady State Conditions in Vivo (2001, background): “These cells are either deleted or persist in extravascular sites (33).”
Tissue-Resident Memory T Cells (2014, background): “Memory T cells can be isolated from SLO, blood-borne compartments, and NLTs (Masopust et al., 2001b; Reinhardt et al., 2001; Woodland and Kohlmeier, 2009), and at least for CD8+ T cells, this may include NLTs that were not sites of infection (Hofmann and Pircher, 2011; Kaufman et al., 2008; Liu et…”