Metabolic control of autophagy.

By L. Galluzzi, F. Pietrocola, Beth Levine, Guido Kroemer. Cell, 2014

797 citations recorded by the source corpus.

Subfields: Epidemiology, Pharmacology, Physiology

View Paper: https://www.semanticscholar.org/paper/fae0e0b8072a50d1afe28b049b732739fe9a7034

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Citations in the corpus

Fundamentals of cancer metabolism (2016, background): “Intracellular proteins and other macromolecules can be recycled through autophagy, a highly regulated process through which proteins and organelles are delivered to the lysosome and degraded (89).”
Obesity and type 2 diabetes mellitus: connections in epidemiology, pathogenesis, and treatments (2023, background): “Generally, the alteration of autophagy (either site-dependently enhanced or suppressed) in the context of obesity is complicated since they depend on various conditions (93) (Figure 4), where the hyperactivation of mTOR under overnutrition leads to the suppression of autophagy owing to the imbalance”
Necroptosis: Mechanisms and Relevance to Disease (2016, neutral): “…and postnatal development, the maintenance of adult tissue homeostasis) (4) as opposed to RCD triggered by exogenous perturbations of the intracellular or extracellular microenvironment, which occurs once adaptive processes such as autophagy or the endoplasmic reticulum stress response fail (5, 6).”
Autophagy and Mitophagy in Cardiovascular Disease. (2017, background): “Besides proceeding at baseline levels in physiological conditions, autophagy responds to a wide variety of microenvironmental triggers, including nutritional, metabolic, hormonal, physical, chemical, and biological cues.(5,6) In the vast majority of these settings, autophagic responses promote adapt”
Autophagy in malignant transformation and cancer progression (2015, positive): “Autophagy is intimately implicated in the maintenance of physiological metabolic homeostasis (Galluzzi et al , 2014; Kenific & Debnath, 2015).”
Molecular definitions of autophagy and related processes (2017, neutral): “…nutritional, metabolic, chemical, physical, and hormonal cues can alter (increase or decrease) the ability of microautophagy, CMA, and macroautophagy to degrade autophagy substrates (Galluzzi et al , 2014; Green & Levine, 2014; Kaur & Debnath, 2015; Mukherjee et al , 2016; Tasset & Cuervo, 2016).”
Mitochondrial metabolism and cancer (2017, background): “That said, however, it should be noted that (1) RCD regulation at mitochondria involves a robust metabolic (rather than purely structural) component; (2) several metabolic aspects of the mitochondrial biology also influence therapeutic responses [101, 169] and (3) metabolic enzymes residing within m”
Metabolic Control of Longevity. (2016, background): “This has been demonstrated in intestinal stem cells, whose function is improved by MTORC1 inhibition in Paneth cells (Yilmaz et al., 2012).”