Discrete Microdomains with High Concentration of cAMP in Stimulated Rat Neonatal Cardiac Myocytes

By M. Zaccolo, T. Pozzan. Science, 2002

897 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/fad8764d4f7781b6c30e724ac47d2eeeedf3ccd1

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Robert E. Campbell
2. A. Ting
3. Roger Tsien
4. Jin Zhang
5. S. Seino
6. John D. Scott
7. T. Shibasaki

In Physiology

1. S. Seino
2. T. Shibasaki

Citations in the corpus

• Creating new fluorescent probes for cell biology (2002, background): “Application of this probe (with CFP and YFP replacing BFP and GFP) in cardiac myocytes showed an unusual compartmentalization of cAM”
• AKAP signalling complexes: focal points in space and time (2004, background): “However, advances in live-cell imaging have visualized gradients, rather than a uniform intracellular distribution, of cAMP, which indicates that this second messenger accumulates at specific sites within cell”
• PKA-dependent and PKA-independent pathways for cAMP-regulated exocytosis. (2005, background): “It has been reported that -adrenergic stimulation generates multiple cAMP microdomains in which the cAMP concentration increases with a range of action as small as 1 m and that free diffusion of cAMP is limited by PDE activities in neonatal rat cardiac myocytes (612).”