AKAP signalling complexes: focal points in space and time

By W. Wong, John D. Scott. Nature reviews. Molecular cell biology, 2004

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Cyclic Nucleotide Phosphodiesterases: Molecular Regulation to Clinical Use (2006, background): “, 1999), several AKAPS (Dodge et al., 2001; Tasken et al., 2001; Wong and Scott, 2004), and several tyrosine kinases (Ekholm et al.”
Molecular basis of AKAP specificity for PKA regulatory subunits. (2006, background): “This scaffolding function permits optimal spatiotemporal resolution and integration of signal transduction pathways (Wong and Scott, 2004).”
Membranes are more mosaic than fluid (2005, background): “Views of the participation of membrane proteins in organizing large functional complexes are beginning to emerg”
Mechanisms of specificity in protein phosphorylation (2007, background): “A-kinase anchoring proteins (AKAPs) are a family of >30 proteins with little sequence homology, but which all bind inactive PKA through the regulatory subunits (reviewed in Ref”
The nuts and bolts of AGC protein kinases (2010, background): “Instead, this is mediated by the multidomain scaffolding proteins known as AKAPs, which bind to the R subunits of PKA heterotetramer”
Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners (2008, background): “While disorder appears to be more clearly associated with date hubs [39,41] than with party hubs, some protein complexes clearly use long regions of disorder as a scaffold for assembling an interacting group of proteins [42,42-50].”