Creating new fluorescent probes for cell biology

By Jin Zhang, Robert E. Campbell, A. Ting, Roger Tsien. Nature reviews. Molecular cell biology, 2002

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Luminescent nanomaterials for biological labelling (2005, methodology): “GFPs have been used as tools in numerous applications, including as biological labels to track and quantify individual or multiple protein species [46], as probes to monitor protein– protein interactions [45, 47, 48], and as biosensors to describe biological events and signals [45, 47].”
Imaging mass spectrometry. (2007, neutral): “…is well established for tracing the distribution of peptides and proteins in tissue sections and GFPderived labeling techniques are now extensively used to study protein dynamics, spatial and temporal, in living systems (Bastiaens & Pepperkok, 2000; Zhang et al., 2002; Phizicky et al., 2003).”
Imaging protein molecules using FRET and FLIM microscopy. (2005, background): “Suitable fluorophores have been developed for FRET and FLIM [40–43] (Table 1).”
Apoptosis: A Review of Programmed Cell Death (2007, background): “…control should be used to ensure that the staining conditions used are able to detect any available cytochrome c. Apoptotic or anti-apoptotic regulator proteins such as Bax, Bid, and Bcl-2 can also be detected using fluorescence and confocal microscopy (Tsien, 1998; Zhang et al., 2002).”