Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial.

By C. Ritchie, Ashley I. Bush, A. Mackinnon, S. Macfarlane, M. Mastwyk, L. Macgregor, L. Kiers, R. Cherny, Qiao-Xin Li, A. Tammer and 9 more. Archives of Neurology, 2003

983 citations recorded by the source corpus.

Subfields: Nutrition and Dietetics, Physiology, Plant Science

View Paper: https://www.semanticscholar.org/paper/faaf8e53542df8e5aef2cd12da7adabb7573a5aa

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Nutrition and Dietetics

In Physiology

Citations in the corpus

Metals, oxidative stress and neurodegenerative disorders (2010, positive): “In addition, the effect of added CQ and Cu on secreted Ab led to rapid degradation through up-regulation of matrix metalloprotease-2 and matrix metalloprotease-3 [41, 42].”
Zinc in the physiology and pathology of the CNS (2009, background): “In a pilot phase II human trial, the oral administration of clioquinol in patients with moderately severe AD for 36 weeks slowed the rate of cognitive decline and caused a reduction in plasma amyloid-β 42 level”
Copper, oxidative stress, and human health. (2005, background): “As is discussed in detail below, several neurological disorders have also been associated with altered Cu metabolism, and Cu/Zn chelators have been used to treat Alzheimer s disease (Regland et al., 2001; Ritchie et al., 2003).”
Oxidative stress in neurodegenerative diseases (2012, background): “[109] Ritchie CW, Bush AI, Mackinnon A, et al.”
Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta. (2008, positive): “Both CQ and PBT2 significantly reduced the production of hydrogen peroxide by As:Cu complexes ( Puglielli et al., 2005 ) (CQ, 49.9%, p < 0.0001; PBT2, 59.2%, p < 0.0001), with PBT2 providing a significantly greater inhibition than CQ (p = 0.01) (Figure 2A).”