Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta.

By P. Adlard, R. Cherny, D. Finkelstein, Elisabeth C L Gautier, Elysia L. Robb, Mikhalina Cortés, I. Volitakis, Xiang M. Liu, Jeffrey P. Smith, Keyla Perez and 14 more. Neuron, 2008

658 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Computational Theory and Mathematics, Physiology

View Paper: https://www.semanticscholar.org/paper/66c3885c8ba05bb7a0f7da5adeaf8bf4a0e3149e

How researchers see this paper

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In Cellular and Molecular Neuroscience

1. Chunyan Guo
2. Xueping Chen
3. M. Valko
4. K. Jomová

In Computational Theory and Mathematics

1. John Hardy
2. Kaj Blennow
3. Richard Frank
4. L. Fass

In Physiology

1. Henrik Zetterberg
2. Kaj Blennow
3. Harald Hampel
4. Chunyan Guo
5. J. Kong
6. Xueping Chen
7. John Hardy
8. M. Valko

Citations in the corpus

• Copper homeostasis and cuproptosis in health and disease (2022, background): “The clioquinol derivative PBT2 has been shown to inhibit Cu-induced Aβ accumulation and possess greater BBB permeability and solubility.(110,111) In a mouse model of AD, the treatment of PBT2 decreases the level of interstitial brain Aβ and the phosphorylation level of tau protein, and lead to the r”
• Therapeutics of Alzheimer's disease: Past, present and future. (2014, background): “Both the compounds bind copper and zinc avidly, prevent their interaction with Ab, decrease oligomerization of Ab and promotes their dissolution; experimental data suggest their beneficial effect on cognition and memory in animals (Adlard et al., 2008; Wang et al., 2012).”
• Oxidative stress in neurodegenerative diseases (2012, background): “When tested in the APP/PS1 transgenic mouse model of AD [110] , PBT2 decreased soluble interstitial Aβ within hours; this was accompanied by improved cognitive performance.”
• Biomarkers for Alzheimer's disease: academic, industry and regulatory perspectives (2010, positive): “Furthermore, a clinical trial on PBT2, which is suggested to affect metal-induced Aβ aggregatio”
• Targeting Free Radicals in Oxidative Stress-Related Human Diseases. (2017, background): “PBT2 is a second-generation 8-hydroxyquinoline derivative of clioquinol [85] which shows an even better ability to cross the blood–brain barrier and reduce the levels of Ab.”