Free fatty acids and pathogenesis of type 2 diabetes mellitus.
By R. Bergman, M. Ader. Trends in endocrinology and metabolism, 2000
644 citations recorded by the source corpus.
Subfields: Physiology, Surgery
View Paper: https://www.semanticscholar.org/paper/fa5af17ab13d1ce6b87a1f529c6243d14e5955a8
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In Physiology
- Ralph DeFronzo
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- Sharon S Elliott
- K. Teff
- Jianping Ye
- Lawrence J. Mandarino
- Silvio E. Inzucchi
In Surgery
Citations in the corpus
- Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach. (2004, background): “Several groups have shown that chronic (6- to 7-wk) overfeeding of a high fat diet impairs insulin secretion in dogs (58, 59).”
- Regulation of insulin action and pancreatic β-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1 (2002, neutral): “1 (14) Insr–/– Foxo1+/– 182 ± 21 (4)* 240 ± 28 (4)* 31.”
- Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40 (2003, background): “: in short-term exposure, FFAs enhance GSIS but under long-term exposure they act to attenuate it; an effect called lipotoxicit”
- Identification of a Lipokine, a Lipid Hormone Linking Adipose Tissue to Systemic Metabolism (2008, neutral): “For example, increased release of free fatty acids (FFAs) from adipose tissue haslongbeen linkedto muscleinsulin resistance ( Bergman and Ader, 2000 ) and lipogenesis and steatosis in liver (Ginsberg et al., 2006).”
- Fructose, weight gain, and the insulin resistance syndrome. (2002, background): “In addition, over time, increased nonesterified fatty acid concentrations may have a deleterious effect on cell function (101).”
- Oral antihyperglycemic therapy for type 2 diabetes: scientific review. (2002, background): “well as augmenting hepatic glucose production (“lipotoxicity”).(19) Therefore, type 2 DM results from coexisting defects at multiple organ sites: resistance to insulin action in muscle, defective pancreatic insulin secretion, and unrestrained hepatic glucose production, all of which are worsened by ”
- Mechanisms of insulin resistance in obesity (2013, background): “Free fatty acid (FFA, also called non-esterified fatty acid) is a risk factor of insulin resistance [82–84].”