Oxidative stress in brain aging. Implications for therapeutics of neurodegenerative diseases.

By R. Floyd, K. Hensley. Neurobiology of Aging, 2002

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Selective Neuronal Vulnerability to Oxidative Stress in the Brain (2010, neutral): “Other RNS species, such as peroxynitrite, are derived from the reaction of nitric oxide with superoxide.”
Studies on free radicals, antioxidants, and co-factors (2007, background): “It is associated with aging and several studies show logarithmic age-dependent increases in oxidized proteins, lipids and DNA in AD patients (Floyd and Hensley 2002); these observed increases are not accounted for by the decreased activity of the antioxidant protective enzymes.”
Calcium and neurodegeneration (2007, background): “When properly controlled, Ca 2+ fluxes across the plasma membrane and between intracellular compartments play critical roles in fundamental functions of neurons, including the regulation of neurite outgrowth and synaptogenesis, synaptic transmission and plasticity, and cell survival.”
Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options (2009, background): “They act as antioxidants to reduce inflammatory cascade induced by oxidative stress [25].”