Non-motor Symptoms of Parkinson's Disease
By J. G. Hou, E. Lai. 2007
733 citations recorded by the source corpus.
SUMMARY In addition to the typical motor symptoms (resting tremor, cogwheel rigidity, bradykinesia, postural instability) of Parkinson's disease (PD), non-motor symptoms are sources of considerable burden in people with PD, espe-cially in elderly patients. The usual non-motor symptoms include cognitive declines, psychiatric disturbances (depression, psychosis, impulse control), autonomic failures (gastrointestinal, cardiovascular, urinary, sexual ability, thermoregulation), sleep difficulties, and pain syndrome. This review article discusses the characteristics, pathophysiology, epidemiology, and management of these symptoms.
Subfields: Epidemiology, Neurology
View Paper: https://www.semanticscholar.org/paper/fa1927f14840b6dc4c8c31a6284ab81f4ab5c4ed
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Epidemiology
In Neurology
Citations in the corpus
- Pathological roles of MAPK signaling pathways in human diseases. (2010, background): “postural abnormalities, rigidity, and akinesia, all of which develop as a result of the loss of 50 to 70% of dopaminergic neurons [47,48].”
- Parkinson's disease: from monogenic forms to genetic susceptibility factors. (2009, background): “It causes motor dysfunctions, such as bradykinesia, resting tremor, rigidity and postural instability, but also affects autonomic functions and cognition (1).”
- The metric properties of a novel non‐motor symptoms scale for Parkinson's disease: Results from an international pilot study (2007, background): “In practice, this meant that the clinician would exlcude patients with significant cognitive impairment that affected either (1) their ability to provide informed consent and/or (2) their ability to provide reliable self-report.”
- Gut microbiota are related to Parkinson's disease and clinical phenotype (2015, background): “DOI: 10.1002/mds.26069 350 Movement Disorders, Vol. 30, No. 3, 2015 be found in earliest stages of PD, sometimes years before motor symptoms appear, and therefore have been suggested as a premotor biomarker.3,6 Which factors initiate the pathophysiological cascade in PD is unknown, but an environmen”