Concurrent overproduction of synapses in diverse regions of the primate cerebral cortex.

By P. Rakić, J. Bourgeois, M. Eckenhoff, N. Zečević, P. Goldman-Rakic. 1986

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Citations in the corpus

Critical Learning Periods in Deep Neural Networks (2017, background): “Synaptic density during development (here shown for the visual cortex of macaques; the green dashed line marks birth and the green stripe is the average synaptic density in a healthy adult, adapted from (33)) follows a similar trend where, after a sharp increase and a peak during early development, ”
Dendritic spines and distributed circuits. (2011, unknown): “Indeed, in neocortex there is a significant pruning of connections during early postnatal development (Katz and Shatz, 1996; Rakic et al., 1986).”
Structural and functional brain development and its relation to cognitive development. (2000, background): “This process of synaptogenesis appears to occur concurrently across diverse regions of the non-human primate cerebral cortex (Rakic et al., 1986).”
Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex (2002, background): “Reports of stable synaptic densities in the adult neocortex should not be viewed as the absence of synaptogenesis but rather as balanced rates of synapse formation and eliminatio”
Trajectories of brain development: point of vulnerability or window of opportunity? (2003, background): “[175] Rakic P, Bourgeois JP, Eckenhoff MF, Zecevic N, Goldman-Rakic”
Translating developmental time across mammalian species. (2001, background): “One neural event was also excluded, a surge in the production of synapses in the developing brain which begins just before birth in primates (Rakic et al., 1986; Zecevic and Rakic, 1991; Missler et al., 1993a,b; Bourgeois et al., 1994; Granger et al., 1995; Huttenlocher and Dabholkar, 1997) or eye…”
Spinogenesis and Pruning Scales across Functional Hierarchies (2009, background): “Presently available data in the primate suggest that there may be different temporal profiles for spinogenesis and pruning in different regions of the cerebral cortex (Huttenlocher and Dabholkar, 1997), and that these profiles may vary among species (Rakic et al., 1986).”
Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models. (2000, unknown): “The timeframe of synaptic development in monkey cortex is the same for areas including somatosensory, motor, and prefrontal cortex (182), suggesting that cell-to-cell communication in the neocortex may be orchestrated by a single genetic or humoral signal.”
Changes of synaptic density in the primary visual cortex of the macaque monkey from fetal to adult stage (1993, methodology): “The density of synaptic contacts per unit volume of neuropil in the striate cortex of adult monkeys is comparable to that in other areas counted from the same set of animals ( Rakic et al., 1986 ).”
Experience-dependent structural synaptic plasticity in the mammalian brain (2009, result): “This corroborates former findings in the developing primate and rodent cortex that synapse densities increase rapidly during a relatively brief postnatal period, followed by a protracted period of net synapse eliminatio”
Compartmentalizing the neuronal plasma membrane from axon initial segments to synapses. (2009, background): “Synapse elimination occurs in order to remove inappropriate or ineffective connections to fine-tune networks (Hashimoto and Kano, 2003; Huttenlocher et al., 1982; Lichtman and Colman, 2000; Rakic et al., 1986).”
Loss of mTOR-dependent macroautophagy causes autistic-like synaptic pruning deficits (2014, unknown): “Postnatal synaptic development in mammalian cerebral cortex is a dynamic process involving concurrent formation and elimination/pruning (Purves and Lichtman, 1980; Rakic et al., 1986).”