Development‐based compartmentalization of the Drosophila central brain

By Wayne Pereanu, Abilasha Kumar, Arnim Jennett, H. Reichert, Volker Hartenstein. 2010

59 citations recorded by the source corpus.

The neuropile of the Drosophila brain is subdivided into anatomically discrete compartments. Compartments are rich in terminal neurite branching and synapses; they are the neuropile domains in which signal processing takes place. Compartment boundaries are defined by more or less dense layers of glial cells as well as long neurite fascicles. These fascicles are formed during the larval period, when the approximately 100 neuronal lineages that constitute the Drosophila central brain differentiate. Each lineage forms an axon tract with a characteristic trajectory in the neuropile; groups of spatially related tracts congregate into the brain fascicles that can be followed from the larva throughout metamorphosis into the adult stage. Here we provide a map of the adult brain compartments and the relevant fascicles defining compartmental boundaries. We have identified the neuronal lineages contributing to each fascicle, which allowed us to compare compartments of the larval and adult brain directly. Most adult compartments can be recognized already in the early larval brain, where they form a “protomap” of the later adult compartments. Our analysis highlights the morphogenetic changes shaping the Drosophila brain; the data will be important for studies that link early‐acting genetic mechanisms to the adult neuronal structures and circuits controlled by these mechanisms. J. Comp. Neurol. 518:2996–3023, 2010. © 2010 Wiley‐Liss, Inc.

Subfields: Biomaterials, Cellular and Molecular Neuroscience, Molecular Biology, Computational Biology & Bioinformatics, Neuroscience

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomaterials

In Cellular and Molecular Neuroscience

In Molecular Biology

In Computational Biology & Bioinformatics

In Neuroscience

Citations in the corpus

Patterns of growth, axonal extension and axonal arborization of neuronal lineages in the developing Drosophila brain. (2009, background): “It then deviates laterally, passes underneath the peduncle, and terminates in a discrete small domain of the CPLd compartment from which the lateral horn develops (Pereanu et al., 2009).”
A connectome and analysis of the adult Drosophila central brain (2020, background): “The LH has been defined as the primary projection target of the olfactory projection neurons (PNs) from the antennal lobe (AL) via several antennal lobe tracts (ALTs) (Ito et al., 2014; Pereanu et al., 2010).”