A connectome and analysis of the adult Drosophila central brain
By Louis K. Scheffer, C. Xu, M. Januszewski, Zhiyuan Lu, Shin-ya Takemura, K. Hayworth, Gary B. Huang, Kazunori Shinomiya, Jeremy Maitlin-Shepard, S. Berg and 99 more. bioRxiv, 2020
884 citations recorded by the source corpus.
The neural circuits responsible for animal behavior remain largely unknown. We summarize new methods and present the circuitry of a large fraction of the brain of the fruit fly Drosophila melanogaster. Improved methods include new procedures to prepare, image, align, segment, find synapses in, and proofread such large data sets. We define cell types, refine computational compartments, and provide an exhaustive atlas of cell examples and types, many of them novel. We provide detailed circuits consisting of neurons and their chemical synapses for most of the central brain. We make the data public and simplify access, reducing the effort needed to answer circuit questions, and provide procedures linking the neurons defined by our analysis with genetic reagents. Biologically, we examine distributions of connection strengths, neural motifs on different scales, electrical consequences of compartmentalization, and evidence that maximizing packing density is an important criterion in the evolution of the fly’s brain.
Subfields: Aging, Cellular and Molecular Neuroscience, Genetics
View Paper: https://www.semanticscholar.org/paper/485fe26cdf8b1ad829b8601986fe4295ac360a52
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In Aging
In Cellular and Molecular Neuroscience
- Gerald M. Rubin
- V. Jayaraman
- Lisa Scheunemann
- D. Owald
- Yoshinori Aso
- Glenn C. Turner
- S. Waddell
- V. Ruta
In Genetics
Citations in the corpus
- A connectome of the Drosophila central complex reveals network motifs suitable for flexible navigation and context-dependent action selection (2020, methodology): “1 of the ‘hemibrain’ connectome—a dataset with 25000 semi-automatically reconstructed neurons and 20 million synapses from the central brain of the fly (Scheffer et al., 2020).”
- Postsynaptic plasticity of cholinergic synapses underlies the induction and expression of appetitive and familiarity memories in Drosophila (2022, methodology): “Without spines, how can input specificity be preserved at MBON postsynaptic densities? KC output to MBON input analysis of the recently published fly hemibrain connectome (Scheffer et al., 2020; neuprint. org; Clements et al., 2020) suggests that, at the ultrastructural level, MBON postsynaptic dens”