Natural Products as Sources of New Drugs from 1981 to 2014.

By D. Newman, G. Cragg. Journal of Natural Products, 2016

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MolNetEnhancer: Enhanced Molecular Networks by Integrating Metabolome Mining and Annotation Tools (2019, background): “Many specialized metabolites from natural sources are used as pharmaceuticals [55], in agriculture [56] or nutrition [57]; however, their discovery is inherently slow due to the above-mentioned limitations.”
Review on natural products databases: where to find data in 2020 (2020, background): “For instance, between 1981 and 2014 over 50% of newly developed drugs were developed from NPs [1].”
The Role of Resveratrol in Cancer Therapy (2017, background): “Phytochemicals such as phytoestrogens have been reported to modulate multiple cellular-signaling pathways, with no or minimal toxicity to normal cells [24,25].”
A Comprehensive Review on Medicinal Plants as Antimicrobial Therapeutics: Potential Avenues of Biocompatible Drug Discovery (2019, background): “In the recent past, humans have been using natural compounds to ward off infections [6].”
A new genome-mining tool redefines the lasso peptide biosynthetic landscape (2016, background): “Natural products have transformed the practice of medicine, where a major percentage of clinically relevant molecules are NPs, mimics, or derivatives 1 .”