Plectasin is a peptide antibiotic with therapeutic potential from a saprophytic fungus
By P. Mygind, Rikke L. Fischer, K. Schnorr, M. T. Hansen, C. Sönksen, S. Ludvigsen, Dorotea S. Raventós, S. Buskov, Bjarke B Christensen, L. Maria and 10 more. Nature, 2005
639 citations recorded by the source corpus.
Subfields: Microbiology, Molecular Biology, Pharmacology
View Paper: https://www.semanticscholar.org/paper/f91e17c3a721a69170e5129649887a2f7e9a5df2
How researchers see this paper
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In Microbiology
- M. Malmsten
- A. Schmidtchen
- Mukesh Pasupuleti
- H. Jenssen
- L. Ringstad
- Joakim Håkansson
- Camilla Björn
- M. Mahlapuu
In Molecular Biology
- L. Ringstad
- Joakim Håkansson
- Camilla Björn
- M. Mahlapuu
- M. Malmsten
- A. Schmidtchen
- Mukesh Pasupuleti
- Robert E. W. Hancock
In Pharmacology
Citations in the corpus
- Bacterial-Fungal Interactions: Hyphens between Agricultural, Clinical, Environmental, and Food Microbiologists (2011, background): “Plectasin targets lipid II, a key component in bacterial cell wall biosynthesis, and thus provides a promising lead for a new antibiotic therapy in the face of the increased incidence of multiple-antibiotic-resistant bacteria in hospitals (269, 345).”
- Antimicrobial peptides: key components of the innate immune system (2012, methodology): “In spite of technical difficulties, plectasin was isolated from the fungus Pseudoplectania nigrella and expressed in Aspergillus sp by using recombinant technology (Mygind et al., 2005).”
- Peptide Antimicrobial Agents (2006, background): “fied lead compounds based on Plectasin, the first defensin to be isolated from a fungus (Pseudoplectania nigrella) (175).”
- Antimicrobial Peptides: An Emerging Category of Therapeutic Agents (2016, background): “In addition, scavenging of the endotoxin LPS by AMPs has been suggested, preventing LPS from binding the TLR4 and triggering inflammation (Lai and Gallo, 2009).”
- Antimicrobial peptides: an overview of a promising class of therapeutics (2007, methodology): “Plectasin, the first fungal defensin with an interesting therapeutic potential, can be produced in a fungal expression system effectively and at high yields, the same system is currently used for industrial scale production of other proteins by Novozyme [93].”