Interleukin-6 stimulates lipolysis and fat oxidation in humans.

By G. van Hall, A. Steensberg, Massimo Sacchetti, C. Fischer, C. Keller, P. Schjerling, N. Hiscock, K. Møller, B. Saltin, M. Febbraio and 1 more. Journal of Clinical Endocrinology and Metabolism, 2003

766 citations recorded by the source corpus.

Subfields: Epidemiology, Physiology, Rehabilitation

View Paper: https://www.semanticscholar.org/paper/f9147f5ce2b6e047391cb842425bbc8011749b27

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Citations in the corpus

The anti-inflammatory effect of exercise. (2005, methodology): “To determine whether physiological concentrations of IL-6 affected lipid metabolism, our group administered physiological concentrations of rhIL-6 to healthy young and elderly humans as well as patients with Type 2 diabetes (105, 149).”
Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase (2009, background): “Unlike the cytokine IL-6, which is upregulated by muscle contractions, leading to altered liver [9] and adipose tissue [42] metabolism, our data suggest that contractioninduced muscle-derived BDNF does not act in a hormonelike manner.”
Muscles and their myokines (2011, background): “Apart from the effects of IL-6 on glucose metabolism, several studies have reported that IL-6 may increase intramyocellular (Bruce and Dyck, 2004; Petersen et al., 2005; Carey et al., 2006) or whole-body (van Hall et al., 2003) fatty acid oxidation.”
Obesity and the role of adipose tissue in inflammation and metabolism. (2006, background): “IL-6 increases lipolysis and fat oxidation in humans (59), and plasma IL-6 concentrations correlate with insulin resistance (55).”
Role of myokines in exercise and metabolism. (2007, background): “Infusion of recombinant human IL-6 into healthy humans to obtain physiological concentrations of IL-6 increases lipolysis in the absence of hypertriacylglyceridemia or changes in catecholamines, glucagon, insulin or any adverse effects in healthy individuals (3, 39, 77) as well as in patients with T”
Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase (2006, background): “Notwithstanding this, the dose administered (5 g/h) did not result in clinical symptoms of sepsis, such as elevated temperature and/or shivering, consistent with previous studies (6,7,13), and the subjects were unable to predict if they were being infused with IL-6 or control.”
Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020, background): “In vivo studies show that rhIL-6 enhances lipolysis and fat oxidation in healthy young and elderly humans (60, 61) and IL-6 autoantibodies appear to be involved in the pathogenesis of a subset of type 2 diabetes (122).”
Exercise is the real polypill. (2013, background): “IL-6 has “leptin-like” actions: through AMPK activation in both skeletalmuscle and adipose tissue (6, 61, 145, 224), it increases glucose uptake (126) and intra-muscle (50, 61, 373) or whole-body (486) lipid oxidation (61, 214).”