Regulation of DNA replication through Sld3-Dpb11 interaction is conserved from yeast to humans.

By Dominik Boos, L. Sánchez-Pulido, M. Rappas, L. Pearl, A. Oliver, Chris P. Ponting, J. Diffley. 2011

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Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP1 (2021, unknown): “Thus, Sld2 and Ddc1 bind to the BRCT4 module while their respective partners in a ternary complex with Dpb11, Sld3 and Fun30, bind to the BRCT1,2 module.”
MTBP, the partner of Treslin, contains a novel DNA-binding domain that is essential for proper initiation of DNA replication (2017, background): “Treslin associates with TopBP1 in a manner that depends upon S-Cdk; this regulated binding is essential for the loading of Cdc45 onto MCM and the consequent initiation of S-phase in vertebrates (Boos et al., 2011; Kumagai et al., 2011).”
DONSON facilitates Cdc45 and GINS chromatin association and is essential for DNA replication initiation (2023, background): “Phosphorylation of Treslin / MTBP by CDKs stimulates their interaction with N-terminal BRCT repeats of TopBP1 and is essential for helicase activation ( 14–15 , 46 ).”
Efficient Initiation of DNA Replication in Eukaryotes Requires Dpb11/TopBP1-GINS Interaction (2013, background): “The N-terminal region containing BRCT1 and -2 interacts with phosphorylated treslin, which is an ortholog of Sld3 (15, 16).”