Endosomal Proteolysis of the Ebola Virus Glycoprotein Is Necessary for Infection
By K. Chandran, N. Sullivan, U. Felbor, S. Whelan, J. Cunningham. Science, 2005
853 citations recorded by the source corpus.
Subfields: Infectious Diseases, Public Health, Environmental and Occupational Health
View Paper: https://www.semanticscholar.org/paper/f908cbdddeda2af405e21eadbf81d164ca6488f2
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Infectious Diseases
In Public Health, Environmental and Occupational Health
Citations in the corpus
- Middle East Respiratory Syndrome Coronavirus: Another Zoonotic Betacoronavirus Causing SARS-Like Disease (2015, background): “However, the recent finding that cathepsin activity is essential for Ebola virus infection in cell lines but not for viral spread and pathogenesis in mice highlights the necessity to confirm the roles of cellular protease inhibitors in in vivo spread of MERS-CoV (229, 230).”
- Distinct Patterns of IFITM-Mediated Restriction of Filoviruses, SARS Coronavirus, and Influenza A Virus (2011, background): “The MARV, EBOV, and SARS-CoV entry proteins each require cathepsin L activity to mediate fusion [10,11,12,13].”
- Structural Characterization of the glycoprotein GP2 Core Domain from the CAS Virus, a Novel Arenavirus-like Species (2013, background): “Within endosomes, GP is cleaved by host cysteine proteases, including cathepsin B and cathepsin L, which cleave GP1 to remove all but an ~17-kDa N-terminal fragment [11].”
- Efficient Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by the Transmembrane Protease TMPRSS2 (2010, background): “duces conformational changes during viral entry following receptor binding and/or endocytosis (6, 20, 28, 31).”
- Virus Entry: Open Sesame (2006, positive): “In some cases, such as for Ebola virus, SARS coronavirus, and the nonenveloped mammalian reoviruses, acidic pH alone is not sufficient to induce fusion, and proteolytic cleavages in viral proteins by acid-dependent endosomal proteases, in particular cathepsins L and B, are needed to trigger the chan”
- Viral membrane fusion (2008, neutral): “, 2008), fusion activation requires cathepsin-mediated cleavage after uptake into the new host cell, stripping GP(1) of much of its mass (Chandran et al., 2005), and subsequent interaction with a specific, endosome/lysosome-resident receptor, the Niemann–Pick C1 (NPC1) protein, a cholesterol transpo”
- Viral membrane fusion (2015, background): “Although the initial cleavage occurs in the producing cell, generating a trimer of disulfide-linked GP(1):GP(2) subunits[46], fusion activation requires cathepsin-mediated cleavage after uptake into the new host cell, stripping GP(1) of much of its mass[47], and subsequent interaction with a specifi”