Enumeration of the Simian Virus 40 Early Region Elements Necessary for Human Cell Transformation

By William C. Hahn, S. Dessain, M. Brooks, J. E. King, Brian Elenbaas, David M. Sabatini, J. Decaprio, R. Weinberg. Molecular and Cellular Biology, 2002

671 citations recorded by the source corpus.

Subfields: Genetics, Oncology, Physiology

View Paper: https://www.semanticscholar.org/paper/f8d43c25d8f0740fb382edb823b07c24086a894f

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Citations in the corpus

Catabolic efficiency of aerobic glycolysis: The Warburg effect revisited (2010, background): “S2c), and that has been shown to be independent of H-Ras expression level or activity [6].”
Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells. (2003, methodology): “…in BJ-TERT/LT/ST/RASV12 cells were as well as others that disrupt of the function of p53, RB, and subsequently tested in a 2-fold dilution series in BJ and BJPP2A (Hahn et al., 1999, 2002; Hahn and Weinberg, 2002; Less- TERT/LT/ST/RASV12 cells to identify compounds that display nick et al., 2002).”
Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells. (2008, background): “The p53DD/CDK4/cyclinD1 combinations substitute for the SV40 large T oncoprotein (Figure 1B; Dolma et al., 2003; Hahn et al., 2002 ).”
A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells (2004, background): “Human embryonic kidney (HEK) cells expressing large T antigen, the catalytic subunit of human telomerase (hTERT) and Ras G12V (hereby referred to as HEK-TER cells) cannot grow in soft agar (a measure of transformed cell growth) or form tumours in mice, unless small T antigen is introduce”
Why do viruses cause cancer? Highlights of the first century of human tumour virology (2010, background): “As cancer is a complex multistep process, it is now obvious that many molecular events, including virus infection, function together to generate the transformed cellular phenotyp”
Comparative biology of mouse versus human cells: modelling human cancer in mice (2003, background): “Immortalized human fibroblasts that ectopically express TERT together with viral oncoproteins that inactivate p53 and RB (such as human papillomavirus (HPV) E6, HPV E7 or SV40 LT) are still not transformed by oncogenic RAS”
Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state (2011, methodology): “In the work described below we used primary HMECs as well as HMECs immortalized with human telomerase (hTERT) that are termed here HME cells (13, 14).”
Species- and cell type-specific requirements for cellular transformation. (2004, background): “…whereas prolonged culturing using a dominant-negative oligomerization mutant of p53 and an INK4a-resistant mutant of CDK4 plus overexpressed cyclinof mouse embryonic fibroblasts (MEFs) under regular culture conditions results in their spontaneous immortalization, compa- D1 (Hahn et al., 2002).”