A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells

By Elisabeth S Yeh, M. Cunningham, H. Arnold, D. Chasse, T. Monteith, G. Ivaldi, William C. Hahn, P. Stukenberg, S. Shenolikar, T. Uchida and 4 more. Nature Cell Biology, 2004

837 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/1722ed61779051d6e4d4e4f4416c1ef680df3035

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In Immunology

1. D. Morrison

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Citations in the corpus

• LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism (2005, background): “A key step in the mechanism regulating Myc degradation involves its GSK3β-dependent phosphorylation on threonine 58 (T58) (Sears et al., 2000; Gregory et al., 2003; Welcker et al., 2004; Yeh et al., 2004).”
• Regulation of Raf-1 by direct feedback phosphorylation. (2005, background): “…bonds (Yaffe et al., 1997), and Pin1 activity has been shown to be re- MEFs, however, Raf-1 exhibited a reduced mobility prior to mitogen treatment and remained shifted at the 4 hrquired for the PP2A-mediated dephosphorylation of Tau, Cdc25C, and Myc (Yeh et al., 2004; Zhou et al., time point.”
• FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation (2008, background): “Indeed, the highly regulated dephosphorylation of S62 has been found to be crucial for MYC instability in vivo in some studie”
• The prolyl isomerase PIN1: a pivotal new twist in phosphorylation signalling and disease (2007, background): “By contrast, PIN1 destabilizes the transcription factor c-Myc and cyclin E, which are important for the G1–S transition at different time point”
• Prolyl cis-trans isomerization as a molecular timer. (2007, background): “In addition, Pin1 increases protein turnover of c-Myc and cyclin E (refs”
• AKT/PKB signaling: navigating downstream. (2007, neutral): “GSK3-mediated phosphorylation of the G1 cyclins cyclin D and cyclin E and the transcripton factors c-jun and c-myc, which all play a central role in the G1-to-Sphase cell-cycle transition, targets them for proteasomal degradation (Diehl et al., 1998; Wei et al., 2005; Welcker et al., 2003; Yeh et al”
• Transcriptional regulation and transformation by Myc proteins (2005, background): “First, Ras controls Myc stability by phosphorylating Myc at two residues, Thr58 (T58) and Ser62 (S62”