The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide.

By G. A. Schellekens, H. Visser, B. D. de Jong, F. V. D. van den Hoogen, J. Hazes, F. Breedveld, W. V. van Venrooij. Arthritis & Rheumatism, 2000

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Angiogenesis in rheumatoid arthritis (2002, background): “ACPA are found in approximately 60 % of RA patients but only in 2 % of the normal population, making them highly specific for RA [22–24].”
Neutrophil Extracellular Traps and Its Implications in Inflammation: An Overview (2017, background): “Autoimmunity is triggered by cPR-3(105-201), a protein complementary to human autoantigen proteinase-3.”
Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteins. (2005, background): “These antibodies are directed against cyclic citrullinated peptides (CCPs) and are highly specific for RA ( 3 ,4).”
Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4. (2005, background): “come citrulline (Schellekens et al. 2000).”
Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis (2003, background): “Assays of antibodies to citrullinated peptide can be used as valuable diagnostic tool”