FSP1 is a glutathione-independent ferroptosis suppressor
By S. Doll, F. Freitas, Ron Shah, Maceler Aldrovandi, M. C. Silva, Irina Ingold, A. G. Grocin, Thamara Nishida Xavier da Silva, Elena Panzilius, C. Scheel and 22 more. Nature, 2019
2,824 citations recorded by the source corpus.
Subfields: Cancer Research, Molecular Biology, Pulmonary and Respiratory Medicine
View Paper: https://www.semanticscholar.org/paper/f847178f21bbb2359ec61664ce12dd724d2aedcd
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cancer Research
In Molecular Biology
In Pulmonary and Respiratory Medicine
Citations in the corpus
- Iron Metabolism in Ferroptosis (2020, background): “…been identified, such as the apoptosis-inducing factor mitochondria-associated 2 (AIFM2)-mediated CoQ10 production pathway (Bersuker et al., 2019; Doll et al., 2019), and the endosomal sorting complex required for transport-III (ESCRT-III)-dependent membrane repair pathway (Dai et al., 2020).”
- CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4 (2022, background): “These small molecules artificially induce ferroptosis by targeting cystine uptake, glutathione (GSH) synthesis, iron loading, glutathione peroxidase-4 (GPX4) activity, and ferroptosis suppressor-protein-1 (FSP1) (Doll et al., 2019) (Bersuker et al., 2019).”
- Ferroptosis in infection, inflammation, and immunity (2021, background): “…(e.g., resulting from apoptosis-inducing factor mitochondria-associated 2 [AIFM2/ FSP1]–mediated coenzyme Q production; Bersuker et al., 2019; Doll et al., 2019; and GTP cyclohydrolase 1–regulated tetrahydrobiopterin synthesis; Kraft et al., 2020) play an alternative role in reducing…”
- Ferroptosis: mechanisms and links with diseases (2021, background): “FSP1 catalyzes the regeneration of non-mitochondrial CoQ10 using NAD(P)H to block ferroptosis by inhibiting the propagation of lipid peroxides.(2,23) Interestingly, membrane targeting of FSP1 via the myristoylation motif of N terminus is essential for its antiferroptotic activity.”
- The cell biology of ferroptosis (2024, positive): “Inactivation of cytosolic GPX4 is likely responsible for ferroptosis in most cases, although mitochondrial GPX4 may be a relevant target in some contexts 37–39 . iFSP1, FSEN1 and related molecules inhibit ferroptosis suppressor protein 1 (FSP1) 42,211 , which blocks ferroptosis from the inner leafle”