The emerging roles of YAP and TAZ in cancer

By Toshiro Moroishi, C. G. Hansen, K. Guan. Nature Reviews. Cancer, 2015

1,055 citations recorded by the source corpus.

Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) are the major downstream effectors of the Hippo pathway, which regulates tissue homeostasis, organ size, regeneration and tumorigenesis. In this Progress article, we summarize the current understanding of the biological functions of YAP and TAZ, and how the regulation of these two proteins can be disrupted in cancer. We also highlight recent findings on their expanding role in cancer progression and describe the potential of these targets for therapeutic intervention.

Subfields: Cell Biology

View Paper: https://www.semanticscholar.org/paper/f83ef93bc31a4ecd9b79a58adf386415ce76cc5a

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In Cell Biology

1. K. Guan
2. Fa-Xing Yu
3. Z. Meng
4. Bin Zhao
5. H. Park
6. Toshiro Moroishi
7. Jung-Soon Mo
8. Young Chul Kim

Citations in the corpus

• Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores. (2017, positive): “Yes-associated protein (YAP) is a mechanosensitive transcriptional regulator with a major role in cancer and other diseases (Moroishi et al., 2015; Plouffe et al., 2015; Zanconato et al., 2016), development (Porazinski et al.”
• Dynamic EMT: a multi‐tool for tumor progression (2021, positive): “Hippo/YAP/TAZ Deregulation of the Hippo pathway was shown to promote tumorigenesis as well (Moroishi et al , 2015 ; Ansari et al , 2019 ) (Fig 4 A).”
• Alternative Wnt Signaling Activates YAP/TAZ (2015, background): “, 2012, 2014b), as well as crosstalk with Wnt or TGFb signaling (Moroishi et al., 2015; Piccolo et al., 2014).”
• Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer. (2015, positive): “Elevated YAP/TAZ expression or nuclear enrichment of YAP/TAZ has been observed in many types of cancers, including liver, breast, lung, colon, ovary, and others (Chan et al., 2008;Moroishi et al., 2015a; Steinhardt et al., 2008).”
• Mechanisms of Hippo pathway regulation (2016, positive): “LATS2 is a direct target gene of YAP/TAZ, and LATS2 mRNA levels are increased upon YAP/TAZ activation (Chen et al. 2015b; Moroishi et al. 2015b).”