Correlating nanoscale titania structure with toxicity: a cytotoxicity and inflammatory response study with human dermal fibroblasts and human lung epithelial cells.

By Christie M. Sayes, R. Wahi, P. A. Kurian, Yunping Liu, Jennifer L. West, K. Ausman, D. Warheit, V. Colvin. Toxicological Sciences, 2006

903 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Materials Chemistry, Renewable Energy, Sustainability and the Environment

View Paper: https://www.semanticscholar.org/paper/f80ab8c657d7ab5d7150b979ba41c65e78b4c8d6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomedical Engineering

In Materials Chemistry

In Renewable Energy, Sustainability and the Environment

Citations in the corpus

Titanium dioxide nanoparticles: a review of current toxicological data (2013, background): “two crystal structures of TiO2, with anatase being more chemically reactive [18,19].”
Toxicity of single walled carbon nanotubes to rainbow trout, (Oncorhynchus mykiss): respiratory toxicity, organ pathologies, and other physiological effects. (2007, background): “based nanomaterials such as carbon nanotubes (CNTs) or carbon nanospheres (“fullerenes”) (Lam et al., 2004; Oberd¨ orster, 2004; Cui et al., 2005), and the effects of metal or metal oxide nanoparticles (Bermudez et al., 2004; Chen et al., 2006; Sayes et al., 2006 ).”
Occupational exposure to titanium dioxide (2011, methodology): “(Heinrich dose data are jittered, i.e., staggered) Data source: Heinrich et al. [1995], Lee et al. [1985, 1986a], and Muhle et al. [1991] 42 NIOSH CIB 63 • Titanium Dioxide in vitro cell assay, cytotoxicity was associated with greater ROS generation from photoactivated TiO 2 [Sayes et al. 2006].”
Nanotoxicology and in vitro studies: the need of the hour. (2012, background): “…titania, have been shown to have toxic effects on epidermal keratinocytes and fibroblasts and are capable of altering their gene/protein expression (Christie et al., 2006; Ding et al., 2005; Monteiro-Riviere et al., 2005; Ryman-Rasmussen et al., 2006; Sarkar et al., 2007; Tian et al., 2006;…”
Crystal structure mediates mode of cell death in TiO2 nanotoxicity (2009, background): “Nantoxicity studies examining the effects of TiO2 have shown induction of inflammatory responses, cytotoxicity, and reactive oxygen species (ROS) formation in a variety of cell types and tissues (Renwick et al. 2004; Warheit et al. 2006; Grassian et al. 2007; Sayes et al. 2006; Gurr et al. 2005; L”
Interactions of nanomaterials and biological systems: implications to personalized nanomedicine (2012, background): “toxic than the rutile form, and that the toxicity correlated with the generation of ROS under UV light [212].”
Nanotechnology and Water Treatment: Applications and Emerging Opportunities (2008, background): “Sayes et al. (2006) *SWCNT – Single-walled carbon nanotubes; #MWCNT – Multi-walled carbon nanotubes. nanoparticles, including TiO2 nanoparticles, of which the results of selected in vivo and in vitro studies are summarized in Tables 3 and 4, respectively.”
Titanium dioxide and zinc oxide nanoparticles in sunscreens: focus on their safety and effectiveness. (2011, background): “As described by Uchino et al and Sayes et al, anatase TiO 2 generally displays the highest photoactivity.(66,67) Uchino et al reported a higher OH production (starting at 10 μg mL−1, 180 mJ cm−2 of 365 nm) for UV-irradiated anatase compared with rutile TiO 2 particles; this was accompanied by higher”
Toxicity of titanium dioxide nanoparticles to rainbow trout (Oncorhynchus mykiss): gill injury, oxidative stress, and other physiological effects. (2007, methodology): “by cytokines) as shown during respiratory TiO2 NP exposure in rodents (Driscoll, 2000; Sayes et al., 2006).”
Titanium dioxide nanoparticles induce DNA damage and genetic instability in vivo in mice (2009, background): “Indeed, previous studies showed that TiO2 nanoparticles have hydroxyl radical activity (39–41) and can also trigger reactive oxygen species production in different cell lines (13, 42) on interaction with the cell membrane or even in cell-free environment (23, 43).”
Particokinetics in vitro: dosimetry considerations for in vitro nanoparticle toxicity assessments. (2007, background): “These are the principal metrics currently in use or proposed for use in conducting in vitro dose-response assessments (Braydich-Stolle et al., 2005; Fubini et al., 2004; Gurr et al., 2005; Hussain et al., 2005; Oberdorster et al., 2005; Sayes et al., 2006; Stringer et al., 1996).”