A central role for central tolerance.

By B. Kyewski, L. Klein. Annual Review of Immunology, 2006

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CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients. (2010, background): “The delicate balance between pathogen-induced effector func- tions and endogenous tolerance-mediating mechanisms is of vital importance to the integrity of a host in the course of an immune response (Kyewski and Klein, 2006).”
Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells (2007, background): “The importance of TEC-derived self antigens for the induction of both dominant and recessive modes of central tolerance is undispute”
Transcriptional Regulation and its Misregulation in Disease (2013, positive): “Self-reactive T cells are normally eliminated during maturation in the thymus, due to the specialized ability of thymic stromal cells, and in particular medullary epithelial cells (MECs), to transcribe a large repertoire of genes encoding peripheral tissue antigens (Kyewski and Klein, 2006).”