Evaluation of current techniques for Ab initio protein structure prediction

By Tom Defay, Fred E. Cohen. 1995

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Bayesian probabilistic approach for predicting backbone structures in terms of protein blocks (2000, background): “It must be noticed that the main characteristics of the PBb’s occurrence matrices are conserved in the both families, as the overexpression of Pro in position ( 12 ).”
Ab initio protein structure prediction: progress and prospects. (2001, background): “The consensus after these first two experiments was that the ab initio structure prediction problem would most probably be solved too late to be applied to any real biological problems (20, 50).”
Prediction of protein side-chain rotamers from a backbone-dependent rotamer library: a new homology modeling tool. (1997, unknown): “However, solving the de novo protein folding problem for a protein sequence of interest has proven very dif®cult (Defay & Cohen, 1995).”