Understanding biofilm resistance to antibacterial agents

By D. Davies. Nature reviews. Drug discovery, 2003

2,685 citations recorded by the source corpus.

Subfields: Molecular Biology, Molecular Medicine, Periodontics

View Paper: https://www.semanticscholar.org/paper/f7bf5c9d932d3c6e0eb1d1fe061a9b5a6f90e2f1

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. S. Ha
2. I. Jahid
3. A. Horswill
4. R. Vasudevan
5. Blaise R. Boles
6. G. Junter
7. M. Simões
8. Fernando Jorge Monteiro

In Molecular Medicine

1. G. Junter
2. A. Horswill
3. T. Jouenne
4. S. Ha
5. C. Beloin
6. J. Mecsas
7. R. Vasudevan
8. J. Ghigo

In Periodontics

1. G. Junter
2. M. Simões
3. Fernando Jorge Monteiro
4. L. Simões
5. M. Vieira
6. A. Horswill
7. T. Jouenne
8. S. Ha

Citations in the corpus

• agr-Mediated Dispersal of Staphylococcus aureus Biofilms (2008, background): “The challenge presented by biofilm infections is the remarkable resistance to both host immune responses and available chemotherapies [6,7], and estimates suggest that as many as 80% of chronic bacterial infections are biofilm associated [8].”
• Liquid-infused structured surfaces with exceptional anti-biofouling performance (2012, background): “For example, exposure to chlorine bleach for 60 min still leaves live cells (8); biofilms in pipes flushed continuously with multiple biocides over 7 d recolonize the pipes (15), and biofilms can survive in bottled iodine solution for up to 15 months (16).”
• Klebsiella pneumoniae: Going on the Offense with a Strong Defense (2016, background): “Bacteria within this structure often become resistant to chemicals to which planktonically grown bacteria may be susceptible (293).”
• Infection of orthopedic implants with emphasis on bacterial adhesion process and techniques used in studying bacterial-material interactions (2012, background): “Therefore, inhibiting bacterial adhesion is essential to prevent implant-associated infection, because biofilm are extremely resistant to both the immune system and antibiotics.(12,13) Therefore, to succeed in orthopedic implants, implant materials must be habitable by bone-forming cells (favoring a”
• Immobilized viable microbial cells: from the process to the proteome ... or the cart before the horse (2004, positive): “The results of PCA also cast doubts on the existence of a unique IC phenotype (Davies, 2003), however, since the nature of the substratum used for biofilm development was shown to contribute to the observed modifications in 2D electropherograms.”
• Strategies for combating bacterial biofilms: A focus on anti-biofilm agents and their mechanisms of action (2017, background): “as a major cause of persistent nosocomial infections in immune-compromised patients.(4,5) Around 50% of the”
• Microbial Biofilm: A Review on Formation, Infection, Antibiotic Resistance, Control Measures, and Innovative Treatment (2023, neutral): “…decreased penetration of the drug [141–147], the biofilm’s modified chemical microenvironment [148–152], and a subgroup of microorganisms in a biofilm that exhibit a form of differentiation similar to spore formation [153–155] all are linked to drug resistance in the biofilm colonies of bacteria [156].”
• Biofilms as Promoters of Bacterial Antibiotic Resistance and Tolerance (2020, background): “Indeed, about 80% of the chronic and recurrent microbial infections in humans are caused by biofilms, some of which result in high mortality and morbidity rates [11,12], particularly those caused by MDR bacteria.”
• A review of current and emergent biofilm control strategies (2010, background): “These processes allow the microorganism to survive and grow (Davies, 2003; Gilbert & McBain, 2003; Mah & O’Toole, 2001; McBain, Rickard, & Gilbert, 2002).”
• Extracellular DNA Chelates Cations and Induces Antibiotic Resistance in Pseudomonas aeruginosa Biofilms (2008, background): “indifference of slow-growing, nutrient-limited cells [30], and unique resistance mechanisms specifically associated with biofilms [31,32].”
• Bacterial biofilm formation on implantable devices and approaches to its treatment and prevention (2018, background): “The Medical Devices Bureau of Health Canada has recognized 4 classes of medical devices based on the level of control necessary to assure the safety and effectiveness of the device that are [95, 96]: 1.”