Bacterial biofilm formation on implantable devices and approaches to its treatment and prevention

By Zohra Khatoon, Christopher D. McTiernan, E. Suuronen, T. Mah, E. Alarcon. Heliyon, 2018

943 citations recorded by the source corpus.

In living organisms, biofilms are defined as complex communities of bacteria residing within an exopolysaccharide matrix that adheres to a surface. In the clinic, they are typically the cause of chronic, nosocomial, and medical device-related infections. Due to the antibiotic-resistant nature of biofilms, the use of antibiotics alone is ineffective for treating biofilm-related infections. In this review, we present a brief overview of concepts of bacterial biofilm formation, and current state-of-the-art therapeutic approaches for preventing and treating biofilms. Also, we have reviewed the prevalence of such infections on medical devices and discussed the future challenges that need to be overcome in order to successfully treat biofilms using the novel technologies being developed.

Subfields: Biomedical Engineering, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/115fbe039e926b9708f463617f1ee5946959acf1

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Citations in the corpus

• Understanding bacterial biofilms: From definition to treatment strategies (2023, background): “, 2019), ultrasonic instruments (Khatoon et al., 2018), and contact lenses (El-Ganiny et al.”