Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness.

By S. Beyth, Z. Borovsky, D. Mevorach, M. Liebergall, Z. Gazit, H. Aslan, E. Galun, J. Rachmilewitz. Blood, 2005

1,057 citations recorded by the source corpus.

Subfields: Genetics, Hematology, Immunology

View Paper: https://www.semanticscholar.org/paper/f778b503720b2b1308abb6bb028d745ef9113f97

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In Genetics

1. Michael A. Matthay
2. N. Singer
3. Frank Barry
4. A. Caplan
5. D. Prockop
6. R. Zemans

In Hematology

1. A. Caplan

In Immunology

1. Michael A. Matthay
2. Vito Pistoia
3. Toren Finkel
4. L. Moretta
5. Antonio Uccelli

Citations in the corpus

• Intrapulmonary Delivery of Bone Marrow-Derived Mesenchymal Stem Cells Improves Survival and Attenuates Endotoxin-Induced Acute Lung Injury in Mice1 (2007, result): “This result is consistent with recent reports demonstrating that MSC do increase production of IL-10 by APCs (9, 27).”
• Mesenchymal stem cells: mechanisms of inflammation. (2011, background): “hMSCs modulate cytokine production by the dendritic and T cell subsets DC1/Th1 and DC2/Th2 (18), block antigen presenting cell (APC) maturation and activation (19), and increase the proportion of CD4+CD25+ regulatory cells in a mixed lymphocyte reaction (20).”
• Mesenchymal stem cells in health and disease (2008, background): “Furthermore, mature DCs incubated with MSCs have decreased cell-surface expression of MHC class II molecules, CD11c, CD83 and co-stimulatory molecules, as well as decreased interleukin-12 ( IL-12 ) production, thereby impairing the antigen-presenting function of the DC”
• Mesenchymal Stem Cells: Mechanisms of Immunomodulation and Homing (2010, background): “similarly found that MSC facilitate T cell unresponsiveness in a cell contact and ratio-dependent manner, which is dictated by the microenvironment [ 26 ] .”
• Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma (2006, background): “Collectively with other studies demonstrating inhibitory effects on dendritic cells (39) and T cells (40), our fi ndings suggest that MSCs can communicate with a variety of cell types and prevent cellular activation in a contact-dependent manner.”