The two faces of IL-6 on Th1/Th2 differentiation.

By S. Diehl, M. Rincón. Molecular Immunology, 2002

892 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

CD4+T Cells: Differentiation and Functions (2012, background): “The inhibition of the Th1 development occurs through the IL6-induced upregulation of suppressor of cytokine signaling-1 (SOCS-1) expression, which interferes with STAT1 activation downstream to IFNγ signaling [49, 50].”
Cytokines in Inflammatory Disease (2019, background): “Interestingly, IL-6 was first described for its effects on adaptive immunity, like promoting cluster of differentiation (CD)4+ T-cells via IL-21 production, and promoting T-cell differentiation towards T-helper2 cells (Th2) and Th17 cells [24].”
Targeting interleukin-6 in inflammatory autoimmune diseases and cancers. (2014, background): “IL-6 is an important modulator to maintain the balance between Th1 and Th2 effector functions (Diehl & Rincon, 2002).”