New developments in solid-state fermentation

By D. Mitchell, N. Krieger, D. M. Stuart, Ashok Pandey. 2000

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Feruloyl esterase from Aspergillus niger a comparison of the production in solid state and submerged fermentation (2002, background): “However, industrial scale-up is much more difficult since heat removal in these systems is often a limiting step [4].”
Exploitation of biological wastes for the production of value-added products under solid-state fermentation conditions. (2008, background): “Various bioreactor types have been used in SSF processes, including packed-beds, rotatingdrums, gas-solid fluidised-beds and other stirred bioreactors [5]; however, the available information does not indicate an ideal bioreactor for solid-state processes.”
Bioactive phenolic compounds: production and extraction by solid-state fermentation. A review. (2011, background): “Themain drawback of this type of cultivation concerns the scaling-up of the process, largely due to heat transfer and culture homogeneity problems (Di Luccio et al., 2004; Mitchell et al., 2000).”
Biotechnological advantages of laboratory-scale solid-state fermentation with fungi (2004, background): “A considerable amount of work has been done in recent years to understand the biochemical engineering aspects of SSF processing (Mitchell et al. 2000a, 2000b; Pandey 2003).”