Role of mitochondrial dysfunction in insulin resistance.

By Yongzhong Wei, James R. Sowers. Circulation Research, 2008

676 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/f6d47c2b5f256d259c2e41493f07bb803dc033f0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. M. Hill
2. Guanghong Jia
3. J. Sowers
4. Barry J. Goldstein
5. Rosario Scalia

In Molecular Biology

1. M. Hill
2. Guanghong Jia
3. J. Sowers

In Physiology

1. M. Hill
2. Guanghong Jia
3. J. Sowers
4. Barry J. Goldstein
5. Rosario Scalia

Citations in the corpus

• Pesticides and human chronic diseases: evidences, mechanisms, and perspectives. (2013, neutral): “Abnormal function of the mitochondrial respiratory chain is the primary cause of imbalanced cellular energy homeostasis and has been widely studied in different types of human diseases most of all diabetes (Abdul-Ghani and DeFronzo, 2008; Kim et al., 2008; Lowell and Shulman, 2005; Ma et al., 2012) ”
• Pathophysiology of Type 2 Diabetes Mellitus (2020, neutral): “characterized by a reduced ratio of energy production to respiration [112].”
• Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities (2010, neutral): “These agents also reduce oxidative stress, although the mechanisms still require clarification (164).”
• Association between insulin resistance and the development of cardiovascular disease (2018, neutral): “Others factors that contribute to diabetic cardiomyopathy pathogenesis Other contributing factors to the diabetic cardiomyopathy pathogenesis are the metabolic abnormalities involving mitochondrial dysfunction, endoplasmic reticulum stress and impaired Ca2+ handling [53, 112, 172, 173].”
• Cellular senescence drives age-dependent hepatic steatosis (2017, neutral): “Furthermore, mitochondrial-derived ROS has been shown to induce telomere dysfunction, thereby contributing to cellular senescence 5 .”
• Diabetic cardiomyopathy: an update of mechanisms contributing to this clinical entity (2018, positive): “Mitochondrial Dysfunction in the Genesis of Diabetic Cardiomyopathy Mitochondrial dysfunction plays a pivotal role in the development of diabetic cardiomyopathy and associated heart failure.(71) Mitochondrial oxidative phosphorylation provides 90% of intracellular ATP production in cardiomyocytes, b”