Pesticides and human chronic diseases: evidences, mechanisms, and perspectives.
By S. Mostafalou, M. Abdollahi. Toxicology and Applied Pharmacology, 2013
1,134 citations recorded by the source corpus.
Along with the wide use of pesticides in the world, the concerns over their health impacts are rapidly growing. There is a huge body of evidence on the relation between exposure to pesticides and elevated rate of chronic diseases such as different types of cancers, diabetes, neurodegenerative disorders like Parkinson, Alzheimer, and amyotrophic lateral sclerosis (ALS), birth defects, and reproductive disorders. There is also circumstantial evidence on the association of exposure to pesticides with some other chronic diseases like respiratory problems, particularly asthma and chronic obstructive pulmonary disease (COPD), cardiovascular disease such as atherosclerosis and coronary artery disease, chronic nephropathies, autoimmune diseases like systemic lupus erythematous and rheumatoid arthritis, chronic fatigue syndrome, and aging. The common feature of chronic disorders is a disturbance in cellular homeostasis, which can be induced via pesticides' primary action like perturbation of ion channels, enzymes, receptors, etc., or can as well be mediated via pathways other than the main mechanism. In this review, we present the highlighted evidence on the association of pesticide's exposure with the incidence of chronic diseases and introduce genetic damages, epigenetic modifications, endocrine disruption, mitochondrial dysfunction, oxidative stress, endoplasmic reticulum stress and unfolded protein response (UPR), impairment of ubiquitin proteasome system, and defective autophagy as the effective mechanisms of action.
Subfields: Molecular Biology, Plant Science
View Paper: https://www.semanticscholar.org/paper/8f230dd4a6154d6cf2418d2e60d959a7f4a9feab
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Citations in the corpus
- Comparative analysis of environmental impacts of agricultural production systems, agricultural input efficiency, and food choice (2017, background): “Conventional practices require more energy use and are reliant on high nutrient, herbicide, and pesticide inputs that can have negative impacts on human health (Townsend 2003, Schwarzenbach et al 2010, Mostafalou and Abdollahi 2013) and the environment (Vitousek et al 2009, Foley et al 2011).”