Increased cell-to-cell variation in gene expression in ageing mouse heart

By R. Bahar, C. H. Hartmann, K. Rodriguez, A. Denny, R. Busuttil, M. Dollé, R. B. Calder, G. Chisholm, B. Pollock, Christophe Klein and 1 more. Nature, 2006

605 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/f6bbd80c3c76e51e3eeaea61e31c49351466221d

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Citations in the corpus

Stems cells and the pathways to aging and cancer. (2008, background): “Stochastic destabilization of transcription resulting from global DNA damage has been implicated in the age-dependent decline of certain postmitotic somatic cells (Bahar et al., 2006), yet this mechanism does not appear to be active in other cell types including stem cells (Warren et al.”
Cellular heterogeneity: when do differences make a difference? (2010, background): “So-called “housekeeping” genes are often chosen as references in assays under the assumption that their variation in expression is small and biologically unimportant (although such assumptions are increasingly challenged; for example, see Bahar et al., 2006).”
DNA damage-induced alterations in chromatin contribute to genomic integrity and age-related changes in gene expression (2008, unknown): “However, there are numerous stochastic changes in gene expression that have no apparent long-term benefit to the organism and may in fact be detrimental (Bahar et al., 2006).”
Stochastic gene expression and its consequences (2008, background): “In one case, researchers showed that the expression of a variety of housekeeping and cell type-specific genes in individual murine cardiac myocytes become increasingly stochastic as the organism ages (Bahar et al., 2006).”
Mitochondrial Dysfunction Accounts for the Stochastic Heterogeneity in Telomere-Dependent Senescence (2007, background): “is a hallmark of the aging process [2–5].”
The hallmarks of aging. (2013, background): “Transcriptional Alterations Aging is associated with an increase in transcriptional noise (Bahar et al., 2006) and an aberrant production and maturation of many mRNAs (Harries et al.”
Four faces of cellular senescence (2011, unknown): “Likewise, cardiomyocytes lose synchronicity of gene expression, which almost certainly affects heart function (Bahar et al., 2006).”