A novel mycolic acid cyclopropane synthetase is required for cording, persistence, and virulence of Mycobacterium tuberculosis.

By M. Glickman, J. Cox, W. Jacobs. Molecules and Cells, 2000

651 citations recorded by the source corpus.

Subfields: Epidemiology, Infectious Diseases, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f686a00617823291db57c358ec075a3c7a773ebd

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Citations in the corpus

Pathway to Synthesis and Processing of Mycolic Acids in Mycobacterium tuberculosis (2005, background): “The gene umaA2 was identified to encode the proximal cyclopropane synthase of -mycolic acid and was renamed pcaA (41).”
Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling (2002, background): “…desA3 and desA2, encoding putative aerobic desaturases, are downregulated. cmaA1 and umaA2 are also downregulated and encode proteins involved in the modification of unsaturated meromycolic acid. umaA2 has recently been found to be required for virulence in M. tuberculosis (Glickman et al., 2000).”
Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti (2002, background): “Changes in colonial morphology are often accompanied by altered virulence (Glickman et al., 2000).”
Mycobacterium tuberculosis: Success through dormancy (2012, background): “Typically, the loss of cell wall components leads to decreased virulence (Glickman et al., 2000; Makinoshima & Glickman, 2005).”
Specialized transduction: an efficient method for generating marked and unmarked targeted gene disruptions in Mycobacterium tuberculosis, M. bovis BCG and M. smegmatis. (2002, methodology): “…of this method has also been shown by several other researchers, who successfully engineered numerous targeted gene disruptions in M. tuberculosis (Glickman et al., 2000; Raman et al., 2001; Sirakova et al., 2001; Steyn et al., 2002), using the reagents described or their derivatives, prior to…”
Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. (2002, background): “For example, the previously annotated umaA2 (Rv0470c), unknown mycolic acid synthase, has recently been changed to pcaA, encoding an S-adenosyl methionine (SAM)-dependent methyl transferase, required for a-mycolic acid cyclopropanation and lethal chronic persistence in M. tuberculosis infection ( Gl”
Mycobacterium tuberculosis Pathogenesis and Molecular Determinants of Virulence (2003, methodology): “tuberculosis physiology and virulence, the structural gene was inactivated by a bacteriophage-mediated system (108).”
The Various Roles of Fatty Acids (2018, background): “cyclopropanation persistence and virulence of the cells Mycobacterium tuberculosis [66]”
Membrane lipid homeostasis in bacteria (2008, background): “tuberculosis being unable to establish a persistent infectio”
Phosphorylation of InhA inhibits mycolic acid biosynthesis and growth of Mycobacterium tuberculosis (2010, background): “…lipids play an important role in the formation of an outer membrane and in cell-wall impermeability, virulence, immune evasion (Dubnau et al., 2000; Glickman et al., 2000; Rao et al., 2006; Bhatt et al., 2007a,b; Dao et al., 2008) and the distinctive acid-fast staining of M. tuberculosis (Bhatt et…”
Who puts the tubercle in tuberculosis? (2007, background): “Mutants defective in either the production of cyclopropane or the addition of cyclopropane to TDM have a markedly enhanced inflammatory response at a comparable bacterial load in murine infection experiment”