Pathway to Synthesis and Processing of Mycolic Acids in Mycobacterium tuberculosis

By K. Takayama, Cindy Wang, G. Besra. Clinical Microbiology Reviews, 2005

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Interpreting Expression Data with Metabolic Flux Models: Predicting Mycobacterium tuberculosis Mycolic Acid Production (2009, background): “Mycolic acids are cell wall components characteristic of mycobacteria and essential for the survival of the bacterium [13].”
Teichoic acids and related cell-wall glycopolymers in Gram-positive physiology and host interactions (2008, background): “The peptidoglycan-anchored mycobacterial arabinogalactans are covalently connected to mycolic acids at the cell surfac”
Production and applications of trehalose lipid biosurfactants (2010, background): “occurs in the final stages of the synthesis of the cell wall [26].”
Drug Discovery Using Chemical Systems Biology: Repositioning the Safe Medicine Comtan to Treat Multi-Drug and Extensively Drug Resistant Tuberculosis (2009, background): “tuberculosis enoyl-acyl carrier protein reductase (InhA), which is essential for type II fatty acid biosynthesis and the subsequent synthesis of the bacterial cell wall [16].”
Phosphorylation of InhA inhibits mycolic acid biosynthesis and growth of Mycobacterium tuberculosis (2010, background): “, 2007a), leading to very long-chain meromycolyl-ACPs (up to C56), which are the direct precursors of mycolic acids (Kremer et al., 2000; Takayama et al., 2005).”