NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth
By Teresa Palomero, W. Lim, Duncan T. Odom, M. Sulis, P. Real, Adam A. Margolin, Kelly Barnes, J. O'neil, D. Neuberg, A. Weng and 7 more. Proceedings of the National Academy of Sciences of the United States of America, 2006
890 citations recorded by the source corpus.
Subfields: Molecular Biology
View Paper: https://www.semanticscholar.org/paper/2abd3ff233bfe91001e03e72864b965e7c81c431
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In Molecular Biology
- Heinz Himmelbauer
- Juliane C. Dohm
- Xose S. Puente
- R. Dalla-Favera
- C. López‐Otín
- C. V. Dang
- Alfonso Valencia
- Roderic Guigó
Citations in the corpus
- MYC on the Path to Cancer (2012, background): “MYC is downstream of deregulated Notch signaling pathways found in T cell leukemia (Palomero et al., 2006; Sharma et al., 2006; Weng et al., 2006).”
- Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation (2011, background): “MYC, one of the target genes and major downstream effectors of NOTCH1 (Palomero et al., 2006; Li et al., 2011), was targeted by trans locations in 9/51 (17.6”
- Notch signalling in solid tumours: a little bit of everything but not all the time (2011, background): “NOTCH1 and MYC probably control two transcriptional programmes that together regulate the growth of primary T-ALL cell”
- Notch signaling: simplicity in design, versatility in function (2011, background): “Genome-wide transcriptome studies in healthy or mutated T-cells (Chadwick et al., 2009; Dohda et al., 2007; Palomero et al., 2006; Weerkamp et al., 2006), mouse embryonic stem (ES) cells (Main et al., 2010; Meier-Stiegen et al., 2010), alveolar epithelial cells (Aoyagi-Ikeda et al., 2011),…”
- Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia (2011, result): “This is consistent with the NOTCH1-mediated activation of multiple biosynthetic routes in T acute lymphoblastic leukaemi”
- Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia (2007, background): “Thus, we considered that inhibition of PTEN by NOTCH1 could be mediated by HES1 and MYC, two transcription factors directly controlled by NOTCH1 (refs”