Uncovering Earth’s virome

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A review of methods and databases for metagenomic classification and assembly (2019, background): “A recent paper, for example, used metagenomic sequencing to discover >125 000 new DNA viruses [149], most of which encode proteins that have no sequence similarity to known isolates.”
Molecular and Evolutionary Determinants of Bacteriophage Host Range. (2019, background): “This is supported by a number of recent metagenomics efforts that have sought to link viral genomes to their hosts [17,18], suggesting that a wide variety of host ranges occur in nature (Figure 1).”
IMG/M: integrated genome and metagenome comparative data analysis system (2016, background): “…as the identification and genomic reconstruction of novel phylogenetic lineages (36), discovery of novel biosynthetic gene clusters (25), identification of alternative genetic codes (37), uncovering gaps in amplicon-based detection of microbial diversity (38) and discovery of novel viruses (39).”
Resolving the structure of phage–bacteria interactions in the context of natural diversity (2021, background): “● Affiliations ○ (1) Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA ○ (2) Department of Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, New York, 10461, USA ○ (3) Department of Microbiology”