Mitelman Database (Chromosome Aberrations and Gene Fusions in Cancer)

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FusionCatcher – a tool for finding somatic fusion genes in paired-end RNA-sequencing data (2014, background): “…ﬁnds 28,399 fusion genes in four cancer breast cell lines[18] whilst: • Cancer Genome Project lists 7,150 known fusion genes 1 [22, 21], and • Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer lists 2,094 known fusion genes 2 [24]. in thousands of cancer cells/patients.”
The emerging complexity of gene fusions in cancer (2015, background): “The t(5;14) chromosomal translocation in a case of acute lymphocytic leukemia joins the interleukin-3 gene to the immunoglobulin heavy chain gene.”
A single oncogenic enhancer rearrangement causes concomitant EVI1 and GATA2 deregulation in leukemia. (2014, background): “Chromosomal inversions and translocations play a central role in the pathogenesis of almost all types of cancers, frequently by formation of oncogenic fusion genes via rearrangement of coding sequences of the involved partner genes (Fröhling and Döhner, 2008; Mitelman et al., 2004, 2013).”