Cancer: An inflammatory link

By F. Balkwill, Lisa M. Coussens. Nature, 2004

678 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/f5c53cea7fdbae09677cf1d8eeb2fcffa91ecd7b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

In Oncology

Citations in the corpus

Inflammation and cancer: how hot is the link? (2006, background): “A number of reports indicate that TNF-a induces cellular transformation, proliferation, and tumor promotion [2,18–20].”
Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. (2006, background): “The inflammatory response to stress-mediated, oncogene-activated necrosis in tumors, by analogy to a wound healing response, may stimulate angiogenesis and tumor cell proliferation (Balkwill et al., 2005; Balkwill and Coussens, 2004; Vakkila and Lotze, 2004;ZehandLotze,2005).Localactivationofaninn”
Clinical impact of different classes of infiltrating T cytotoxic and helper cells (Th1, th2, treg, th17) in patients with colorectal cancer. (2011, background): “However, through inflammation-dependent mechanisms, the innate immune system can promote tumor development (2, 3).”
Molecular Inflammation: Underpinnings of Aging and Age-related Diseases (2008, background): “leukemia and in several virally induced tumors (Balkwill and Coussens, 2004; Chen et al., 1999).”
Tumor necrosis factor antagonist mechanisms of action: a comprehensive review. (2008, background): “A central mediator in this relationship is TNF via its role in NF-κB regulation (Balkwill & Coussens, 2004).”
Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis. (2008, background): “SDF-1/CXCR4 has been implicated in the recruitment of hematopoietic stem and progenitor cells (Balkwill and Coussens, 2004; Jin et al., 2006; Mohle et al., 1998; Peled et al., 1999; Urbich and Dimmeler, 2004), supporting our observation that Gr-1+CD11b+ cells are hematopoietic progenitors.”
Role of chemokines in tumor growth. (2007, background): “Environmental predisposing insults such as ultraviolet light and asbestosis result in chronic inflammation leading to development of melanoma, squamous cell carcinoma and mesothelioma, respectively [1-3,5].”
The tumor microenvironment and its role in promoting tumor growth (2008, background): “It has been proposed that the NF-kB pathway plays a key role in activation of signaling in cancer cells as well as tumor-infiltrating leukocytes (Balkwill and Coussens, 2004; Greten et al., 2004; Pikarsky et al., 2004).”
Polarization of Tumor-Associated Neutrophil (TAN) Phenotype by TGF-β: “N1” versus “N2” TAN (2009, background): “…65.8% of the CD8 + T cells to Various types of myeloid cells have been shown to promote tumor progression by direct immune suppression (Mantovani et al., 2002), as well as by producing angiogenic factors, matrix-degrading enzymes, or growth factors (Balkwill and Coussens , 2004; Luo et al., 2006).”
Regulation of reactive oxygen species generation in cell signaling (2011, background): “…is tightly controlled; however, deregulated TNF-α production causes chronic inflammation, which is directly associated with a variety of diseases such as cancer, inflammatory bowel diseases, arthritis, sclerosis, and Alzheimer’s disease (Balkwill and Coussens, 2004; Chen and Goeddel, 2002).”