Molecular signature of CD8+ T cell exhaustion during chronic viral infection.

By E. Wherry, S. Ha, S. Kaech, W. Nicholas Haining, S. Sarkar, V. Kalia, Shruti Subramaniam, J. Blattman, Daniel L. Barber, Rafi Ahmed. Immunity, 2007

2,141 citations recorded by the source corpus.

Subfields: Genetics, Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/f57f8061190142f7b36b2a4b591fbcf2560c129d

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Citations in the corpus

Type 1 diabetes (2002, neutral): “Together, the coexpression of multiple IRs, reduced but not ablated proliferative capacity, and the ability to be further down-regulated by IR triggering suggest that DH cells have a partially exhausted – like phenotype ( 39 ).”
Defining T cell states associated with response to checkpoint immunotherapy in melanoma (2018, positive): “Data are represented as mean ± SEM. model of chronic LCMV infection (Wherry et al., 2007), and in resident memory T cells (Mami-Chouaib et al., 2018).”
Gene expression markers of Tumor Infiltrating Leukocytes (2016, background): “The list also includes well-known markers for exhausted CD8 cells [12-14] and FOXP3 for Tregs.”
Bioenergetic insufficiencies due to metabolic alterations regulated by PD-1 are an early driver of CD8+ T cell exhaustion (2016, background): “Differences between in vitro studies and the current data might be due to differences between in vitro activated Teff-like cells and in vivo generated Tex cells that are transcriptionally and phenotypically distinct from Teff cells (Doering et al., 2012; Wherry et al., 2007).”
From Vaccines to Memory and Back (2010, positive): “In the case of certain chronic viral infections antigen specific T and B cells express a variety of inhibitory receptors that result in functional exhaustion of these cells (Barber et al., 2006; Virgin et al., 2009; Wherry et al., 2007).”
Redefining chronic viral infection. (2009, positive): “The inhibitory receptor PD-1, a CD28 family costimulatory/coinhibitory molecule, regulates CD8 T cell exhaustion during chronic LCMV infection in mice (Barber et al., 2006; Wherry et al., 2007).”
Tumor-Specific T Cell Dysfunction Is a Dynamic Antigen-Driven Differentiation Program Initiated Early during Tumorigenesis (2016, positive): “…of D8 TCRSV40-I from pre-malignant lesions with D8 exhausted virus-specific CD8+ T cells in chronic LCMV (clone 13) infection (Figures 5A and S5; Wherry et al., 2007), as well as D30 TCRSV40-I with D30 exhausted virus-specific T cells (Figure 5B and Table S2) using previously identified gene…”
VEGF-A modulates expression of inhibitory checkpoints on CD8+ T cells in tumors (2015, background): “In tumors or during chronic viral infections, PD-1 expression is maintained (Wherry et al., 2007).”