p53- and Mdm2-Independent Repression of NF-κB Transactivation by the ARF Tumor Suppressor

By S. Rocha, K. Campbell, N. Perkins. 2003

197 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f50950865a2ae45a04df8df39c7b0775ff9b6aae

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Citations in the corpus

To be, or not to be: NF-κB is the answer – role of Rel/NF-κB in the regulation of apoptosis (2003, background): “ARF inhibited NF-kB-mediated transcription in a promoter-specific manner and downregulated expression of the antiapoptotic Bcl-xL protein (Rocha et al., 2003a).”
Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. (2003, background): “…has p53-independent functions—including the repression of ribosomal RNA synthesis, the inhibition of NF- B activity, and the targeting of E2F for degradation—suggesting that a number of other pathways are impaired by INK4A/ARF loss (Martelli et al. 2001; Rocha et al. 2003; Sugimoto et al. 2003).”
Good cop, bad cop: the different faces of NF-κB (2006, background): “In addition to p53, the ARF tumor suppressor also regulates RelA activity.(51,71) ARF expression, which is induced by oncogenes, results in activation of p53 through binding to and inactivation of Hdm2/Mdm2.”
IκB Kinase α-Mediated Derepression of SMRT Potentiates Acetylation of RelA/p65 by p300 (2006, background): “The transactivation potential of RelA/p65 is repressed by phosphorylation at threonine 502 by p14 or by glycogen synthase kinase 3 -induced phosphorylation of RelA/p65 at S468 (11, 51, 52).”
Integrating cell-signalling pathways with NF-κB and IKK function (2007, background): “By contrast, phosphorylation at Thr505 by the CHK1 checkpoint kinase, which can be activated by ATM- and Rad3-related (ATR) kinase in response to ARF tumour suppressor induction or DNA damage following cisplatin treatment, inhibits RelA transactivation and results in its increased association with H”
Transient and Selective NF-κB p65 Serine 536 Phosphorylation Induced by T Cell Costimulation Is Mediated by IκB Kinase β and Controls the Kinetics of p65 Nuclear Import 1 (2004, background): “p14-mediated repression of p65 trans activation requires threonine 502 phosphorylation (28) within p65 trans activation domain 2 (TA2).”