Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated.

By S. Demaria, B. Ng, M. Devitt, J. Babb, N. Kawashima, L. Liebes, S. Formenti. International Journal of Radiation Oncology, Biology, Physics, 2004

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An Abscopal Response to Radiation and Ipilimumab in a Patient with Metastatic Non-Small Cell Lung Cancer (2013, background): “Cancer Immunol Res; 1(6) December 2013 Cancer Immunology Research 368”
Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy (2006, background): “After irradiation of a tumor, T cells are probably required to mediate distant tumor growth inhibition (35, 36).”
Combining radiotherapy and cancer immunotherapy: a paradigm shift. (2013, background): “Similarly, an abscopal effect was seen in a mouse model of breast cancer (98).”
Cytokines and their relationship to the symptoms and outcome of cancer (2008, background): “Evidence from animal models suggests that local irradiation of a tumour can result in regression of distant non-irradiated tumours, an effect that is mediated by T cell”
Stereotactic Radiation Therapy Augments Antigen-Specific PD-1-Mediated Anti-Tumor Immune Responses via Cross-Presentation of Tumor Antigen (2014, background): “Initial pioneering work by Demaria and colleagues (31) combined XRT with Flt3-L and documented an abscopal effect in contralateral shielded tumors that was immune mediated (31, 32).”