An Abscopal Response to Radiation and Ipilimumab in a Patient with Metastatic Non-Small Cell Lung Cancer

By E. Golden, S. Demaria, P. Schiff, A. Chachoua, S. Formenti. Cancer immunology research, 2013

638 citations recorded by the source corpus.

The combination of local radiotherapy to a liver metastasis and systemic anti-CTLA-4 antibody resulted in a sustained complete clinical and radiologic remission in a patient with chemotherapy-refractory metastatic non–small cell lung cancer. A posteriori evidence suggests that radiotherapy to a targeted tumor can elicit an immune-mediated abscopal (ab-scopus, away from the target) effect in nontargeted tumors, when combined with an anti-CTL antigen-4 (CTLA-4) monoclonal antibody. Concurrent radiotherapy and CTLA-4 blockade induced immune-mediated abscopal effects in poorly immunogenic preclinical tumor models and patients with metastatic melanoma. However, no such reports exist for patients with metastatic lung adenocarcinoma. We report the first abscopal response in a treatment-refractory lung cancer patient treated with radiotherapy and ipilimumab (a human anti-CTLA-4 monoclonal antibody). A posttreatment increase in tumor-infiltrating cytotoxic lymphocytes, tumor regression, and normalization of tumor markers was observed. One year after treatment with concurrent radiotherapy and ipilimumab, the patient is without evidence of disease. Cancer Immunol Res; 1(6); 365–72. ©2013 AACR.

Subfields: Immunology, Oncology, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/f9bbb3d5243203b72b5b957dc124bee75c90eb45

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In Immunology

1. A. Mantovani
2. P. Allavena
3. Charles G. Drake
4. A. Sica
5. C. Garlanda
6. J. Pollard
7. F. Balkwill
8. D. Hanahan

In Oncology

1. P. Allavena
2. A. Mantovani
3. Charles G. Drake
4. A. Sica
5. Lisa M. Coussens
6. M. Karin
7. J. Pollard
8. F. Balkwill

In Psychiatry and Mental health

1. P. Allavena
2. A. Mantovani

Citations in the corpus

• The interaction of anticancer therapies with tumor-associated macrophages (2015, background): “In a breast cancer model, cessation of anti-CCL2 therapy was associated with monocyte release from the bone marrow, increased mobilization and infiltration of cancer that were distant from the treated site (abscopal effect; Durante et al., 2013; Golden et al., 2013, 2014).”
• Stereotactic Radiation Therapy Augments Antigen-Specific PD-1-Mediated Anti-Tumor Immune Responses via Cross-Presentation of Tumor Antigen (2014, background): “Moreover, several clinical case reports provide evidence of synergy between combined XRT and immune checkpoint blockade (29, 30).”