Regeneration and orthotopic transplantation of a bioartificial lung

By H. Ott, Benjamin Clippinger, C. Conrad, C. Schuetz, I. Pomerantseva, L. Ikonomou, D. Kotton, J. Vacanti. Nature Medicine, 2010

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Acellular normal and fibrotic human lung matrices as a culture system for in vitro investigation. (2012, background): “In experimental rodent models, we and others have demonstrated an ability to regenerate functional lungs (13, 14) and heart (15) by repopulating acellular matrices with various cell types.”
An overview of tissue and whole organ decellularization processes (2011, background): “The potential advantage of tissue specificity formaintaining selectedcell functionsandphenotypehasbeensuggestedbystudiesof cells and ECM isolated from tissues and organs such as the liver [9,48], respiratory tract [10,30], nerve [49], adipose [50], andmammarygland [51].”
Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function (2014, methodology): “After culture within a bioreactor, the organs were reimplanted into syngeneic recipients and demonstrated efficient gas exchange (Ott et al., 2010; Petersen et al., 2010).”
The use of whole organ decellularization for the generation of a vascularized liver organoid (2011, result): “Recent studies by Ott et al.(13,40) and Uygun et al.”