Mucins in the mucosal barrier to infection
By S. Lindén, Philip E. N. Sutton, N. Karlsson, V. Korolik, M. McGuckin. Mucosal Immunology, 2008
1,184 citations recorded by the source corpus.
The mucosal tissues of the gastrointestinal, respiratory, reproductive, and urinary tracts, and the surface of the eye present an enormous surface area to the exterior environment. All of these tissues are covered with resident microbial flora, which vary considerably in composition and complexity. Mucosal tissues represent the site of infection or route of access for the majority of viruses, bacteria, yeast, protozoa, and multicellular parasites that cause human disease. Mucin glycoproteins are secreted in large quantities by mucosal epithelia, and cell surface mucins are a prominent feature of the apical glycocalyx of all mucosal epithelia. In this review, we highlight the central role played by mucins in accommodating the resident commensal flora and limiting infectious disease, interplay between underlying innate and adaptive immunity and mucins, and the strategies used by successful mucosal pathogens to subvert or avoid the mucin barrier, with a particular focus on bacteria.
Subfields: Immunology, Microbiology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/f3f778dcfb8f496f82024cf856d7546ef29baf7b
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Citations in the corpus
- Muc2 Protects against Lethal Infectious Colitis by Disassociating Pathogenic and Commensal Bacteria from the Colonic Mucosa (2010, background): “The mucin gene family contains 16 known members in humans that can be broadly divided into membrane bound or secretory forms [15].”
- Mucin glycan foraging in the human gut microbiome (2015, background): “Specialty section: This article was submitted to”
- Bacteriophage adhering to mucus provide a non–host-derived immunity (2013, background): “5–5 nm from the peptide core outward into the surrounding environment (17, 18).”
- How microorganisms use hydrophobicity and what does this mean for human needs? (2014, background): “This question is especially justified for hydrophilic microorganisms living on inner or outer human body surfaces, which have mostly hydrophobic character (Gilbert et al., 1991; Feingold, 2007; Linden et al., 2008).”
- NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion. (2014, neutral): “The resultant intestinal mucus layer consists of two stratified layers and plays a key role in the maintenance of intestinal homeostasis; it protects the epithelium from dehydration, physical abrasion, and commensal and invading microorganisms (Johansson et al., 2008; Linden et al., 2008).”